Unless your external drive enclosure is rated USB 3 and the SSDs are rated SATA 3 (6GBps), you will not see much improvement in speed over your current internal drive. Internals in 21.5-inch iMacs, unless built to order with something better, are 5400rpm SATA 2 (3GBps) models. A USB 2 external enclosure with a max transfer rate of 480MBps will be a serious performance setback.
The fastest of these slow factory-installed internal mech drives have actual read/write speeds in the range of 90-100MBps. A USB3 enclosure with 6GBps SSDs is rated at up to 5GBps, and actuals will be about 400MBs. Nice boost.
To confirm your external drive going to be fast enough, open System Profiler and click "USB" in the left-hand Contents pane. If the drive is connected you will see this:
If you see the 5GBps speed and your SSDs are 6GBps models. you should see a decent performance boost if your intenal is purely mechanical.