Go step by step and test.
1. Empty Caches from Develop menu twice.
Use the developer tools in the Develop menu in Safari on Mac ...
2. Remove website data;
https://support.apple.com/en-gb/guide/safari/sfri11471/13.0/mac/10.15
3. If Safari doesn’t load website pages
https://support.apple.com/guide/safari/if-you-cant-open-a-website-ibrw1071/mac
If you can’t open a Safari window on Mac
4. In some cases, this can happen if adware, anti-virus software or cleaner type application are installed.
To find out, run EtreCheck and post the report here.
https://etrecheck.com
Click “Free download” button,
Open Downloads folder, click on it to open, and then select ”Open”.
“Choose a problem” from the popup menu box, and then “Start EtreCheck” in the dialog.
Click “Share Report” button in the toolbar, select “Copy report” .
Paste the report when you reply.
5. Contact Adobe Support.