Strange boot problem with Mid 2010 Mac Pro desktop running OS X El Capitan
I'm experiencing a strange boot-up problem with my mid-2010 Mac Pro desktop computer.
When performing a soft reboot (Apple Logo --> Restart...) my computer will shut down and begin the reboot sequence as usual (chime, Apple logo, progress bar), however a little passed the half way point of the progress bar, I get a greyed-out prohibited symbol (circle with a diagonal bar through it) and nothing more happens.
However, if I press the power button for a second or two and shut the computer down manually, then restart it by pressing the power button again, the computer boots up just fine.
I've tried a PRAM reset to no avail.
I then installed a fresh version of El Capitan on one of my internal SSD drives (I have two installed) then restarted using the new install to run disk utility's First Aid function on the primary drive. The problem is still present.
Does anyone have any experience with this and what could be going on?
Mac Pro, OS X 10.11