Might be review, might not be...
VPN clients connecting directly into an organization’s private network, yes.
VPN clients into a commercial VPN provider, no.
Those provide easily breached security due to the pre-determined credentials, and you should already be using VPNs (TLS or otherwise) for your connections.
If the local part of the network path is a concern and a commercial VPN provider client is of interest, consider running your own VPN server and connect to that, if you don’t trust your ISP or first hop. Or migrate your connections to trusted DNS and connections to TLS, as should already have happened as that protects all the hops.
As for IP connections, macOS is dual-stack and whichever is the lower-cost path will be used.
When DNS servers are in the mix, whichever one is first up and that then returns an authoritative answer will be used. If you have a private internal IPv6 DNS configuration in the target network, that’ll need to be the selected DNS server or hosts known (only) to that DNS server will not translate.