I can’t able to open safari . Error code 501

Goodness me Manu, stop being so impatient, we are all users like you, so it is up to us when and whether or not to answer you.

Have you tried restarting your mac and then opening Safari.

If it still will not open then try installing the High Sierra 10.13.6 Combo update.

https://support.apple.com/kb/DL1970?viewlocale=en_US&locale=en_US

Once downloaded double-click to install.