External display stops working after some time

Given:

Catalina 10.15.5

MBP 16'' 2.4 i9 64ram 5500M Radeon 8GB

CalDigit TS3 Plus Firmware 44,1

LG 4k HDR 27UK600-W connected with DisplayPort cable

What happens

At first everything is working fine (except up colors in HRD mode), but after some time, usually a day, after wake up, Mac OS cannot recognize Display any more, it just does not exist. Restarting display does not help, restarting TS3 Plus does not help, restarting MacBook Pro does help, so possibly it must be something wrong with Mac OS. Anyone experiencing similar issue?

[Edited by Moderator]