Hope all is well joaonew,
Thanks for the additional information.
We tested this site and discovered the same behavior, that in Safari it doesn't open a new Mail message, and that in Chrome it does offer a new Mail message. In Safari, if you hold down the Send Mail button on the site, it will pop up with the options New Mail Message, Add to Contacts, and Copy Email. This sounds specific to the site.
If you are able to reproduce the issue in an additional iOS device, this may be a matter of how Safari is reading the PDF. This could also still be related to the file itself. It's extremely possible that Safari in iOS is not redirecting the links to a specific app in iOS. Safari in iOS may also have configurations you'll want to check. Review the information listed below.
"Content blockers are third-party apps and extensions that let Safari block cookies, images, resources, pop-ups, and other content."
Here's how to get a content blocker:
- Download a content blocking app from the App Store.
- Tap Settings > Safari > Content Blockers, then set up the extensions that you want. You can use more than one content blocker.
This information and more about Safari configurations can be found here: Clear the history and cookies from Safari on your iPhone, iPad, or iPod touch.
Additionally, check Settings > Safari > Advanced > Experimental Features. Toggle on LinkPrefetch.
Afterwards, go to Settings > Safari and turn off Block Pop-ups. This is temporary to find out if there's a security feature in place blocking the links.
If you still can't open the two links while viewing the PDF in Safari, check if the links open in the PDF once it's imported to Books. Learn more about Books here: Read PDF documents in Books on iPhone.
Stay awesome!