What is the safest antivirus for Big Sur IOS

None. Do not install any third party antivirus apps. They interfere with the OP's builtin protection, use system resources while providing no benefit, and they may cause problems.

macOS - Security - Apple

Set up your Mac to be secure - Apple Support

Protect your Mac from malware - Apple Support

Effective defenses against malware and ot… - Apple Community

Read the info at the last link I posted above.

MalwareBytes is not an antivirus app. It is a diagnostic tool. It is often recommended here as is Etrecheck. I too often recommend both of these apps when troubleshooting.

There is no "safest" AV program to install. Generally, AV apps do more damage than good. They create a huge demand for system resources resulting in the machine slowing down, then they generally don't work very well for the performance hit it demands.

The best thing to do is to always remain current on MacOS updates.

Installing future OS updates, and being careful about where you download software from. If you need a tool, click here.

(187907)