The game's developer, Blizzard, has explicitly stated in their support forums that the considerably poorer performance on Mac compared to Windows systems (with all hardware more or less equal) is due to poor OpenGL drivers being used with Mac OS X 10.6.4. They've stated quite clearly (and, probably with accuracy) that it is Apple's job to implement the newest/best drivers with their OS.
This is corroborated by Steam, which urged Steam users on Macs to avoid the 10.6.4 upgrade as the drivers included negatively impacted graphically intensive games provided by that service.
And, to the other poster, I'm playing the game on a late 2008 MBP that easily meets the recommend Windows requirements, yet is at the low threshold for the Mac minimum requirements. The perform difference on the same machine, playing between bootcamp and OSX, is really appalling.