unable to open recently downloaded apps
Since about early December 2020, I have been unable to open newly downloaded apps. I download, start the .dmg file and app is placed in Applications folder. Dbl-click the app. Icon appears in my dock, then nothing. Rt-click the dock icon and the window says 'force quit'. I reinstalled Catalina last week with no change. Happens to 'small apps' (e.g. CleanMyMac or AppCleaner) or 'big apps' (e.g., Luminar AI and Topaz Studio; both are photo editors). No amount of restarts or reinstalls have worked. Customer assistance is stumped. Our Apple store is closed (pandemic) and the local Apple accredited repair shop is taking service reservations for April and beyond.
Any ideas what's going on and how to fix?
MacBook Pro 13″, macOS 10.15