iTunes not saving a very simple setting under Preferences

If iTunes is apparently installed correctly try the following in turn until iTunes opens/closes/reopens/connects to the store/saves preferences normally: Most likely to help in bold.

• Remove any SD card that might be in a card reader.
• Exit the BTTray.exe Bluetooth utility if installed.
• Locate the shortcut for iTunes, right-click on it, and select Run as administrator. Doing this once may fix certain launch issues. Some users were finding that with the 12.6.1.25 build, for example, they had to use this method every time and modified the shortcut accordingly.
• Try holding ctrl+shift as you launch iTunes so it opens in safe-mode. Again doing this once may sometimes help.
• Try disconnecting your computer from the Internet before running iTunes.
• Delete the iTunes shortcuts from the start menu, desktop, task bar, or similar, then repair iTunes from the programs and features control panel.
• Try Fix unexpected quits or launch issues in iTunes for Windows - Apple Support (document retired, archived copy) and test the behaviour in a different user profile or with a different library. If the problem only exists in your profile it may be possible to delete some of the iTunes preference files which it would seem that iTunes may be choking on. We can go into details later if the issue is limited to your own profile.
• Temporarily disable any non-Microsoft anti-virus and see if that has any impact on the behaviour.
• See the second box in Troubleshooting issues with iTunes for Windows updates for detailed tear down and rebuild advice. Disable any non-Microsoft anti-virus software when reinstalling and run the installer as the administrator.
• If you installed iTunes from the Microsoft Store you may find the traditional iTunesSetup.exe installer works better for you, or vice versa.
• Or see the iTunes installers section of the troubleshooting tip and reinstall the last version that worked correctly for you. Links to the latest builds are now at the very bottom of the user tip.

tt2

Welcome, jrsousa2!

From your post, it sounds like you are experiencing an issue with setting changes being saved in iTunes. We're glad that you reached out to the Apple Support Communities. We want to try and help you find the answers you need.

If you have not already tried, restart your computer. Often this simple step will refresh the apps and software on the device to solve numerous problems you may encounter.

Is the iTunes software on your computer up-to-date? If not, update your iTunes software. Here's how to Update to the latest version of iTunes. We hope this information helps you out.

Take care!

jrsousa2 Said:

"iTunes not saving a very simple setting under Preferences: I started iTunes as admin (doing this always, since upon closing it won't stay put (it reopens tirelessly), and then when I uncheck "warn me if itunes is not the default play" (why would I want it to be the default player?), it doesn't save it!!! I did this a few times and the check mark stays there! Any clues?"

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Use Safe Mode:

Along with updating your iTunes, try making this change in Safe Mode [Hold Down: shift key upon boot]. In Safe Mode, login items do not open at log in; only necessary preferences are run, and damages items are intentionally replaced and fixed.