USB disconnects in browser after upgrade to Big Sur 11.4

Hi, I have an issue where my USB (Ledger Nano S) gets disconnected regardless which browser I use. Specific error msg varies between browsers. In Safari: "Ledger Error undefined is not an object (evaluating 'navigator.usb.getDevices')

The USB worked fine up until the upgrade.

I've tried;

• MacOS 14.4 (just updated).
• Nano S. FirmWare 2.0.0 (latest version)
• Have reset the PRAM/VRAM (command+option+p+r)
• Tried different cables and different usb ports
• Tried different browsers; Safari, Brave, Firefox, opera

Note: I tried connecting via a friends Win10 laptop and it worked fine with no issues.

Tastes a bit like an MacOS issue to me.

Any ideas on resolution?