CleanMyMac is one of those things that can put a load on your system, and/or delete things it shouldn't. So you should at least launch
Applications -> Utilities -> Activity Monitor -> View (menu) -> All Processes -> CPU (tab)
And keep an eye on any processes that are consuming a lot of CPU. There are also Memory, and Networking tabs if you want to peek at them as well. Just make sure CleanMyMac is not consuming resources that should be going to transferring YouTube videos, and processing them via the graphics and audio drivers for display on your Mac.
I do not have anything against Malware bytes. It does not implement a firewall.
If you do not know what a VPN is, then it is unlikely you are using one. But to explain, a VPN is a "Virtual Private Network". The original use was to allow employees to securely connect to their company's internal network without bleeding all the company secrets across the internet. In the past few years there have been consumer VPN companies that claim to keep your internet browsing a secret from your ISP, from coffee shop owners, etc... as well as allow users in another country access country limited content by having the VPN exit node being the foreign country so the content distribution service thinks they are a resident of the country. For example watching BBC shows from another country. The only problem with this is, many of those consumer VPN services just vacuum up your web surf'ing data and sell it on the side.
What web browser are you using to view YouTube. Have you considered trying a different web browser?
- Safari
- Firefox
- Brave
- Chrome
- Microsoft Edge
- other...
Another trick to try "JUST AS AN EXPERIMENT", boot into Safe mode
http://support.apple.com/kb/ht1564
This will not load any 3rd party utilities (yes, CleanMyMac will not be running), but Safe mode is an easy way to see if 3rd party software is causing your issues. NOTE: Safe mode uses a much more conservative video driver, so you may see some lines flicker across your screen. As this is just an experiment, it is nothing to worry about.