First, there is no reason to ever install or run any 3rd party "cleaning", "optimizing", "speed-up", anti-virus, VPN or security apps on your Mac. This user tip describes what you need to know and do in order to protect your Mac: Effective defenses against malware and other threats - Apple Community.
There are no known viruses, i.e. self propagating, for Macs. There are, however, adware and malware which require the user to install although unwittingly most of the time thru sneaky links, etc.
Anti Virus developers try to group all types as viruses into their ad campaigns of fear. They do a poor job of the detecting and isolating the adware and malware. Since there are no viruses these apps use up a lot of system resources searching for what is non-existent and adversely affect system and app performance.
There is one app, Malwarebytes, which was developed by a long time contributor to these forums and a highly respected member of the computer security community, that is desshoigned solely to seek out adware and known malware and remove it. The free version is more than adequate for most users.
Also, unless you're using a true VPN tunnel, such as between you and your employer's or bank's servers, they are useless from a privacy standpoint: Public VPN's are anything but private.
That being said you've installed what most of the experienced contributors to these forums consider to be akin to malware: CleanMyMac. Also you still have Avira installed. Uninstall both according to the developer's instructions.
Also your're running PowerMate which states this on their website:
The Powermate USB has been discontinued as of 2018 and is not designed to work past High Sierra for Mac
You can check to see if you've removed all of the supporting files by downloading and running the shareware app Find Any File to search for any files with the application's or the developer's name in the file name. For the mentioned software you'd do the following search(es):
1 - Name contains power mate
2 - Name contains cleanmymac
3 - Name contains macpaw
4 - Name contains avira
Any files that are found can be dragged from the search results window to the Desktop or Trash bin in the Dock for deletion.
FAF can search areas that Spotlight can't like invisible folders, system folders and packages.
If you need a replacement for PowerMate to create and run macros give Keyboard Maestro a try. It's extremely powerful and can perform the most amazing macros. I have over 100 macros with it.
You have a number of apps being launched at login and running in the background. If you still are worried about performance after getting rid of the previously mentioned apps you can limit the apps that are launched at login in. Particularly SpeedTest and AppCleamer. Those can be launched when needed and the closed to free up system resources.
