i have a mid 2010 macbook pro and a new 2021 ipad pro the ipad is not recognize by itune

See if this document helps:

'If your computer doesn't recognize your iPhone, iPad, or iPod'

click here --> https://support.apple.com/HT204095

If you are using iTunes make sure it is the absolute newest. Check for updates:

Update to the latest version of iTunes - https://support.apple.com/HT201352

A few users of High Sierra have reported needing to delete iTunes and reinstalling iTunes in order to get the latest version.