Will Canon DR-M160 work on Big Sur

I believe it will.

Give the VueScan scanner software (Hamrick Software) a try.

https://www.hamrick.com

Please read Writing an effective Apple Support Communities Question . Your question is incomplete, in order for us to assist you have to help us too. We are all volunteers and are happy to help you but leaving the question incomplete such as telling what a DR-M160 is would be help, which version of Mac OS is installed and what if any research you have done.