Thanks for your info. Jan.
I've tried all or most possibilities so far, including clearing and reloading the printer drivers from Epson, and uninstalling and reinstalling Photoshop. All to no avail.
I only use a direct USB connection for my important printers, so I bypass any challenges with AirPrint.
The thing that is clear is. that this problem is exactly what happened when Big Sur 11.6.1 was released. That didn't just affect me, but rather a whole community of Mac users who printed with ICC Profiles.
I've now come across a printer company who have issued a short video recommending that a) you don't update to 12.2.1 and if you have, back track to 12.2 until this gets sorted out.
Back in December when I discovered that those with Monterey had no problem, I was able to move to Monterey. It immediately returned all my printing processes and ICC availability to normal. This time, I have no choice but to go back one version. I can't wait for Apple to fix things because I have prints that I need to deliver. I'll be working this out with Apple Support later today.
When I look through the Mac filing system to Macintosh HD/Library/Printers, I can find the Epson files and all the proper Epson Paper ICC profile, so I know it has been set up properly by the Epson drivers. It is worth noting that you can't find the Epson ICC Profiles in the place where all the 3rd party profiles are located. Epson don't offer those as standalone files, at least to my knowledge. The Epson ICC Profiles come with the Epson printer drivers and get loaded in this location with the other printer software. Nevertheless, it has worked properly for me for 11 years, so I guess Epson worked it out with Apple and Adobe at some point.
I will say this for coming across such problems, it sure helps me to learn more and more about my computer and applications.
Regards,
Jack