When you look at Bluetooth, are there other devices connected or trying to connect, other than the mouse or keyboard you normally use? Are you connected to a hub or dock?
Spotlight indexing normally happens with the screen in saver mode (or with the screen off) with no impact on the screen.
Do you have any network monitoring tools, Little Snitch, third party firewalls or any antivirus or security tools? Anything at all that updates itself in the background? (Lots of software does that, by the way.)
If the answer is no to everything, I would try an experiment to troubleshoot. Disconnect from WiFi and from the internet and everything else except the mouse and keyboard (replace them with wired ones if you have them, in which case you can turn off Bluetooth as well). This test need only last a few minutes, then you can go back to normal connections. If it still won't go into screen saver properly, then something is installed most likely causing this. In which case, download and run Etrecheck and post the output (it is anonymous) here with the Additional Text button below.