Can you bring Mac Studio on an Airplane?

Security won't know what to do with it, and may prevent you from boarding with it.

For laptops, they have been trained that a laptop that can power up and "look alive", cannot have any substantial amount of bad stuff inside.

Since there is no such guidance for computers like the Mac Studio, their response may be to prevent you from carrying it on. You should be prepared to leave it at the gate, and there is always a possibility that it will be stolen before it gets back to you.

Just to be clear, you want to bring a desktop computer with monitor on a commercial flight and use it while on said flight? Aside from the limited space inside coach (unless you're flying business/first class) and the question if security will let you bring a monitor inside the terminal, the other concern would be sufficient outlet power inside the plane.

Oh ok. You should be fine taking it on the plane if you get it through security