Better Node layout

So here's a question on which node layout would obtain the fastest render times:

FileIn(TIF image, in:-inf, out: +inf)->Fade(keyframes 0@50, 1@51, 0@100, 0@199, 1@200, 1@250, 0@251)->Over

or use duplicate FileIn nodes and utilize the in/out timing parameters

FileIn(TIF image in:51, out:100)->Over
FileIn2(TIF image in:200, out:251)->Over

Thx.