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Please restart the computer in Safe Mode per the directions in the  How to use safe mode on your Mac - Apple Support link. 

Note: If you are using a wireless keyboard please either plug it in using the supplied Lightning cable that shipped with it. If you are using a legacy keyboard or a third-party keyboard that does not have re-charging abilities, please use any USB keyboard. Also note that a Safe Mode restart may require you to hold down the shift key for up to 5 minutes before the computer starts in Safe Mode. You will know it is in Safe Mode when you see “Safe Mode” in the upper right of the display.

After restarting in Safe Mode, then restart normally and test.

Please look in System Preferences - Mouse and look for the preferences you selected and test each.

Also, by chance is there any third party antivirus, cleaning or any other third party maintenance apps installed on the computer??

Try changing the Accent color in System Preferences > General.

Welcome.