Normally we would advise you to boot into Safe Mode to test things, but since the Wacom tablet requires a driver this is not a possibility since Safe Mode disables third party software & drivers from launching during boot & login. It still may be worthwhile to reboot the Mac into Safe Mode anyway since it does run a file system check as well as deleting some temp & cache files which can cause problems. Sometimes booting into Safe Mode, then immediately rebooting will sometimes fix things.
To look for possible software issues run EtreCheck and post the report here using the "Additional Text" icon which looks like a piece of paper. Usually software such as anti-virus apps, cleaning apps, and third party security software are the culprits when users experience problems with their Macs. If you have any of these types of apps installed, then uninstall them by following the developer's instructions.
If you don't have those types of apps installed, then it may be worthwhile to install macOS 12.6 to an external USB3 SSD like @Old Toad mentioned just to confirm whether a clean install of macOS 12.6 will work with the Wacom tablet software & driver. Do this without migrating/restoring from a backup and do not install any other third party software except for the most recent version of the Wacom software & driver. If this works, then it proves you have some sort of software or configuration issue with the other installation. If it does work, then you can migrate/restore to the external boot drive to make sure the Wacom tablet & software continue to work as an extra test.