Hi David
Way over-simplified, size and model also matters.
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The graphic's line-up is probably the most important consideration when buying a used 06.
The Early 2006 17 and 20" Core Duo models have a dedicated ATI graphic's card
http://support.apple.com/kb/SP35
The Late 17" Core 2 Duo model has a GMA 950 graphics processor.
The Late 20" Core 2 Duo model has a dedicated ATI graphic's card.
The Late 24" Core 2 Duo model has a NVIDIA 7300GT or upgraded NVIDIA 7600 GT
http://support.apple.com/kb/SP28
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Personally I know of at least 5 other Early 06 Core Duo's +(including mine)+ and a few Late 06 Core 2 Duo's that were bought new and still work just fine. Out of all those +(knock on wood)+ only 1 Late 17" had the Logic board and HD replaced by Apple Care over a year ago. Remember that those models are 4½ and 4 years old respectably and it's not surprising that a fair % have either been replaced by a newer model, passed on to family or just passed-on.
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Just me, but if I was shopping for a used 06, I would go with either with one of the Early 17" or 20" models, or the Late 20" model.
Dennis