Corrupt Owner Account (Ventura)

First, there is no reason to ever install or run any 3rd party "cleaning", "optimizing", "speed-up", anti-virus, VPN or security apps on your Mac.  This documents describe what you need to know and do in order to protect your Mac: Effective defenses against malware and other threats - Apple Community and Recognize and avoid phishing messages, phony support calls, and other scams - Apple Support.  

There are no known viruses, i.e. self propagating, for Macs.  There are, however, adware and malware which require the user to install although unwittingly most of the time thru sneaky links, etc.   

Anti Virus developers try to group all types as viruses into their ad campaigns of fear.  They do a poor job of the detecting and isolating the adware and malware.  Since there are no viruses these apps use up a lot of system resources searching for what is non-existent and adversely affect system and app performance.

There is one app, Malwarebytes, which was developed by a long time contributor to these forums and a highly respected member of the computer security community, that is designed solely to seek out adware and known malware and remove it.  The free version is more than adequate for most users.  

Since you've tried the Safe Mode boot try the following in order as necessary:

1 - boot into the Recovery volume (boot with the Command + R keys held down  - Intel Macs) or  (How to Boot an M1 Mac into Recovery Mode), select Disk Utility and run First Aid on all available volumes. Reboot normally and see if the problem persists.

2 - repeat #1 but this time reinstall the system. This will not affect the user data.

Try launching Safari while holding the Shift key which should start Safari in Safe Mode. If this works, then you can check your browser extensions for a problem and clearing the browser cache. There may be some other Safari setting you can check on clearing (I don't use Safari so I don't know what options are available).

If this does not work, then try deleting the Safari .plist preference file in the user accounts hidden Library/Preferences folder. I'm not sure what other preference files there may be.

Please run Etrecheck and post its full report here. Use the "additional text" button and paste the report into the text box.

You're welcome. I only just found out about the Shift + Open option for launching Safari app in Safe Mode from another more knowledgeable contributor. Glad it worked and you were able to resolve this issue.