OmniDiskSweeper, as others have mentioned is probably the quickest way to find the largest occupants of your internal disk storage.
Photos, Music, and email (and email attachments) will most likely occupy the most space. Do NOT delete anything in your Macintosh or User Libraries.
You should also report back here as to what you do and the results of your efforts. That may help others with the same problem.
I have a daughter that never cleans out the Downloads folder and never empties Trash or Mail Trash. "What if I can't find what I want and have go get it again?" Trash is just that, and not temporary storage!..I gave up and add an external drive so she could periodically transfer the oldest files to that.