2 esim and one physical sim. Will it work?

Per Apple: On your iPhone, you can store eight or more eSIMs, which will be there whenever you need them. You can have two eSIMs active on supported iPhone models at the same time. 

If you have an iPhone with a SIM slot, you can have that and one eSIM active, or two eSIM and no active SIM: Using Dual SIM with an eSIM - Apple Support (iPhone 13 models and later also support two active eSIMs. iPhone models without a physical SIM tray support two active eSIMs.)

Basically, you get two active lines total, whether each is SIM or eSIM.

The dual SIM models have no eSIM.

iPhone 14 models sold in the U.S. can have 2 active eSIM. There is no SIM slot.

So, the answer to your question would be "no" if you live in the U.S.

Or are you asking about an iPhone 14 model that is sold in another country?

In that case, you can have 1 eSIM active and 1 SIM active and the answer to your question would still be "no".