If your iPad is not performing as expected immediately after performing a system software update, try a forced restart - as this will often clear an isolated issue:
Force restart iPad (models with Face ID or with Touch ID in the top button)
If your iPad doesn’t have the Home button, do the following:
- Press and quickly release the volume button nearest to the top button.
- Press and quickly release the volume button farthest from the top button.
- Press and hold the top button.
- When the Apple logo appears, release the top button.

Force restart iPad (models with the Home button)
Press and hold the top button and the Home button at the same time. When the Apple logo appears, release both buttons.

This support page may be helpful with (re)pairing and use of the Pencil with your iPad:
Connect Apple Pencil with your iPad - Apple Support
If you continue to experience difficulties, here is one of the better troubleshooting guides:
https://appletoolbox.com/apple-pencil-not-working-heres-our-troubleshooting-guide/