After the Sonoma 14.4 update, Mac mini keeps crashing and restarting

Though I seldom use it, I uninstalled CleanMyMac as you suggested. I also tried to stop Adguard and test.

Now I think it's all about macOS itself. I boot to safe mode and then sleep the MBP. The system crashes and reboot itself in about 10 minutes.

Same machine as yours and zero issues even with the latest Sonoma 14.4.1 released Monday ( Yesterday )

To avoid the question / answer and question answer scenario

Restart in Safe Mode. This will perform a Disk Repair, clear cache files and only load Apple Software, extensions and fonts. The boot up will be slow and can take some time - Normal.

Safe Mode will also eliminate Third Party Software, extensions and drivers from loading.

It will only load the Minimum amount of Core Apple Processes to allow the the computer to function at a reduced Level of Performance 

Does the issue present in this mode ?

Sometimes a Safe Boot followed by a Normal Boot will just put things right.

If not - there could be something in the main User Account playing up. To further isolate this - Set up users, guests, and groups on Mac. Then log out of the Main User account and log into the dummy account and test again if the issue persists.

If the issue is present in the dummy account - then, this appears to be a System Wide issue on the computer.

Download the Application Etrecheck  ( External Link ) directly from the Developer.

The Application is Not a " Silver Bullet "  and is  only a tool to examine the Hardware / Software used on this computer 

This is a Diagnostic Tool that makes no changes to the computer Hardware / Software used on this computer 

The application is free or paid from added features. 

The Report will Not Reveal Any Personal Information. 

Post back the Full Report - copy and paste - >>>> using the Additional Text Icon ( 3rd Icon to last ) <<<<

Lastly - should you decide to use and post the Report now or at a later time, we are willing to have a very close look and offer some insights 

More than one antivirus app - This computer has multiple antivirus apps installed.

CleanMyMac, and AdGuard

Roll my eyes and say CleanMyMac aka BrickMyMac claims Yet and other Victim

How to erase all content and settings

Specific to CleanMyMac aka “ BrickMyMac “

To put the CleanMyMac in context and the damages it may have or has already done.

This application can or will Muck Up your User Account ( Home Folder ) of this machine.

It does not touch the Operating System itself unless you consider your User Account ( Home Folder ) as part of the Operating System

Then in that specific context - it has Mucked Up the Operating  System 

I was wrong. Still persists in macOS 14.4.1.

With respect, unless there was a Hardware failure , not lightly it is macOS issue.

Unlike MS Windows computers where most of the Hardware is pieced together from various Third Party components.

Apple designs the components to their specific specifications to work with macOS

macOS is specifically designed to work with specific Apple Computers

To close out, have presently, 1 M1, 2 M2 and 1 M3 all running Sonoma 14.4.1 without a single crash

But then again, I have never every installed an Disk Cleaner, Disk Optimizers, Third Party Security Software.

Had I and knowing what is known about these softwares.

Would have taken a different route that you have and used the Erase All Content and Setting, the start again from scratch

To each there own

Good luck with this ongoing computer issue

With respect, unless there was a Hardware failure , not lightly it is macOS issue.

Unlike MS Windows computers where most of the Hardware is pieced together from various Third Party components.

Apple designs the components to their specific specifications to work with macOS

macOS is specifically designed to work with specific Apple Computers

To close out, have presently, 1 M1, 2 M2 and 1 M3 all running Sonoma 14.4.1 without a single crash

But then again, I have never every installed an Disk Cleaner, Disk Optimizers, Third Party Security Software.

Had I and knowing what is known about these softwares.

Would have taken a different route than you have and used the Erase All Content and Setting, the start again from scratch

To each there own

Good luck with this ongoing computer issue

I visit an Apple store today. I'm told that there may be something wrong with the motherboard and screen (with sensors). It's not about the software update. So they would replace them for me. With Apple Care+, it'll be free. I'm waiting for the components.

I have tried to boot to safe mode and reboot back to normal. It did not solve the problem. Here is the full report.

Thank you in advance.

I think it's the same on my 2021 M1 MacBook Pro. Something crashed after it went to sleep a few minutes. And then I heard start up sound.

I tried macOS 14.4.1. It seems to have fixed the problem.

A visit to Apple Store helps me. The screen and motherboard are replaced and everything returns normal. So I met a hardware problem instead of software one.