can I have different email signatures for each of my icloud addresses?

For example, I use one of my iCloud emails for work, so I want it to have a work appropriate signature. I use another for my music, so I want a music appropriate signature. Is this possible? I know I can have different signatures with different email accounts, but the iCloud ones are really just forwarders. I'm thinking specifically for my iPhone, but it would be handy on the desktop too.