Chrome is by far the largest resource consumer that is not obvious malware. ANY other Browser has a lighter footprint, generally with no loss in performance. Chrome will cause more activity in every facet of the operation of your Mac.
CleanMyMac just guesses at what to remove, and has been known to attempt to remove parts of running MacOS. Clean My Mac empties cached data, which makes you RAM sparkling clean, while your Mac is slowed by having to re-read stuff that was cached, but has now been discarded. CleanMyMac fails the test of being benign, AND it does not properly remove all traces of CleanMyMac when asked to do so using the official maker's procedure. In my opinion, that makes it indistinguishable from Malware.
VPN you install yourself offers NO additional security. In fact, it concentrates your information of the VPN site for easier data harvesting, and several have been caught doing exactly that, despite their assurances that they do not do that. You get needless complexity and abuse for NO added benefit whatsoever.
if you need a VPN to be 'present' on an institutional network, the Institution will provide the VPN and support its use.
if you need anonymity comparable to the Federal Witness Protection Program, use Tor Browser -- that is why it exists.
Otherwise, all the stuff we have been discussing should GO.