Mac doesn't manage output audio signal to external interface Motu M4

Hi everyone.

I have a Mac Mini M2 Pro connected to a MOTU M4 audio MIDI interface.

Often I turn on the Mac and the Motu DOES NOT shows the output signal line, so no sound comes out of the speakers, even though the audio settings are correct. I then have to do a restart and at that point it starts working.

The problem is identical both with a Mac Mini M2 Pro with 16RAM (used until a couple of days ago), and with an identical machine but with 32RAM.

I have always installed the most recent version of the Motu drivers/firmware on my computer.

This problem bothers me a lot, given the money spent to have this type of hardware.

Can anyone tell me a possible permanent solution, please?

Thank you .