Error -50 is an input-output error of some sort. Could be the format, or a corruption, or could be the source or destination storage hardware is failing.
macOS can read most NTFS volumes, but cannot write to them.
If you have an add-on tool such as Paragon NTFS installed, check for updates to that.
You can try dismounting everything, unplugging it all, and rebooting and reconnecting. That might clear things.
Does this error also happen when copying from NTFS external to internal, or from internal to APFS?
Is the data on the NTFS external volume available on Mac, or Windows running elsewhere? (Is there a source of data that doesn’t involve this USB external?)