Keep the iPhone updated to the latest iOS always and never Jailbreak. That's it.
iOS / iPadOS devices cannot be infected with Virus / Malware / Spyware *** unless you have intentionally downloaded spurious software or unauthorized apps directly from the internet and installed them on your device or/and have Jailbroken.
It (Hacking) also depends on how careful you are in sharing sensitive and valuable information pertaining to your iPhone such as Passcode, Password, etc with your friends and family members.
Be judicious when sharing the device's sensitive and valuable information with friends and family members.

**The primary reason for this is Sandboxing. All third-party apps are “sandboxed”, so they are restricted from accessing files stored by other apps or from making changes to the device. Sandboxing is designed to prevent apps from gathering or modifying information stored by other apps.
Security of runtime process in iOS and iPadOS - Apple Support

The sandbox on an iPhone is a security feature that creates a restricted environment for each app to run in isolation from other apps and the operating system. It is a core component of iOS's security architecture and plays a crucial role in making iPhones more secure.