Mac USB stops working randomally after update to Sequoia

Brad Hyman wrote:

Thanks much. Since I have installed or used any new software since initially upgrading to Sequoia, I know this is either a bug within the Sequoia OS.

if there is a corrupt plist I would try toggle some changes here and compare your results, then come back to your preferred settings:

ref: If your Mac asks you to allow an accessory to connect - Apple Support

A SafeBoot Start up your Mac in safe mode - Apple Support will sort many anomalies

Does a quick disk repair before it fully boots up, and certain system caches get cleared and rebuilt, third party system modifications and system accelerations are disabled temporarily.

you can Login and test. Reboot  as normal and test.  Caches get rebuilt automatically.

Brad Hyman wrote:

I have found that my Mac USB keyboard will randomly stop working after update to Sequoia. It has done this with all versions of Sequoia since it's initial release.

and CleanMyMac and nothing seems to resolve the issue.

I even when so far as to re-image the MacStudio from scratch and not the migration assistant or restore from TimeMachine.

well what I can say is your CleanMyMac is certainly know to cause issue...I would start there:

Uninstall all third party apps that are Cleaners/Optimizers/VPN/Anti-Virus

all known to cause issues on the macOS

To be proactive you can file a bug report / submit your Apple Feedback here: Product Feedback - Apple