idenizen wrote:
Hello, I was wondering if anybody could assist me in getting rid of spam messages in the message center? They even appear when I have Safari closed. They appear to be from mac-uptodate.com, which when I try that site is a 404.
I've attached a screenshot. I do have an antivirus program running as well.
Thanks
https://discussions.apple.com/content/attachment/e2ba1a54-25b7-4bc9-81b5-5805e172ccc6
Third party garbage/spam I would look for some in-app or official uninstaller if your App supplies one.
if in doubt search the developers website or contact their: Support/Help/FAQ/Known issues/compatibility/updates…
Compare your results after that.
see if your Safari >Settings>Websites...associated with your " mac-uptodate.com" in Notifications & Pop up Windows to squish.

Third party AntiVirus is not recommended— it typically does nothing but add issues to the macOS and competes directly with Apple’s own built in security:
macOS - Security - Apple macOS - Security - Apple
Apple Platform Security - Apple Apple Platform Security - Apple Support
Uninstall all third party apps that are Cleaners/Optimizers/VPN/Anti-Virus
all known to cause issues on the macOS
Recognize and avoid phishing messages, phony ...
Recognize and avoid social engineering schemes including phishing messages, phony support calls, and other scams - Apple Support
Protecting against malware in macOS
Protecting against malware in macOS - Apple Support
Effective defenses against malware and other threats… - Apple Community
Effective defenses against malware and ot… - Apple Community