How to clear system and app cache on macbook pro?

Yes, clearing cache files can help free up some storage space on your Mac, especially if cache files have accumulated significantly over time. However, be cautious to avoid deleting important system or application files. Here's a safe and effective way to clear cache on MacBook Pro (2019, macOS Sequoia 15.5):

1. Close All Applications

Quit all running applications to prevent conflicts.

2. Access Cache Folders

• You can manually delete cache files from the Finder:
• Open Finder.
• Click Go in the menu bar.
• Select Go to Folder....
• Enter the following paths one at a time and delete cache files inside:
• System caches: /Library/Caches
• User caches:
• ~/Library/Caches

Note: The ~ refers to your home directory.

3.Delete Cache Files Safely

• In each folder, you can select the files and folders inside and move them to Trash.
• Do not delete the entire Caches folder itself, just the contents inside.
• Empty Trash afterward.

In general a Restart clear up the caches, returning them to best case (small) sizes until you re-launch your Apps.

...but as soon as you start working agin, caches (used to speed up operating your Apps) will be re-populated with the cached information.

Caches are what allows you Mac to run fast. Caches are not the enemy.

With storage running so low, an external drive is recommended as more robust long-term solution.

A large Photo library or Music library can be easily moved to an external drive. Other items can take slightly more planning, but not very difficult.

The issue appears to be low storage space if you only have 30GB of free space on a 512GB SSD. I doubt this is a cache or system data issue.

Free up storage space on Mac - Apple Support

System Data (formerly called Other) is mainly your own data stored by apps in the hidden Library folder.

What is “Other” storage on a Mac, and how… - Apple Community

80 GB is not a very large value for System Data. It isn't worth pursuing in your case when you have 384 GB of storage that can be much more easily managed.