Have you tried the suggestions posted at the top of this thread by karel250? I have also seen posts somewhere, don't recall where, that non-English keyboard with special characters cause problems. If this applies to you then you might want to check for that.
I too have been having problems backing up over the wire to my DS216+II in the past few weeks (Mac Mini M4 running 26.2). My TM logfile was filled with errors and although I could hear my hard drives working during a backup and see the restore selections, the errors bothered me enough that I purchased a well known 3rd party backup solution.
Today I spent a lot of time deleting my TM backups and setting it all up again as new. I had to use Synology Filer to delete all the files in my TM directory on the NAS, I did not delete the TM folder on the NAS. Snapshots are saved locally on my Mac, I had to use Disk Utility to delete all those snapshots and remove the mounted partition to NAS. I deleted TM setup in System Settings and then Shutdown and did a 'Recovery Startup' (sorry, I don't know the proper name) and started up without doing a recovery option (not a normal startup after shutdown). I did this to wipe the caches and whatever residual memory of TM's prior install. No idea if that was necessary.
I set up TM again, making sure I followed the suggestions of karel250 and the Synology Knowledge base article on TM. I use SMB3 and NOT afp. I reused same NAS directory, UID, and pw as I had in the past. It took nearly 3 hours over ethernet to complete a new backup and appears to be in good order but only after the next few days/weeks will I know for sure. Unfortunately, I no longer trust this method of backup and having purchased the 3rd party solution it backs up the /data folder in about 3 minutes via thunderbolt vs almost 3 hours over ethernet. I'll keep using TM scheduled backups but I'm going to be relying on my new backup solution.
Good luck, hope this helps