Extensions not turning on due to error in macOS Sequoia 15.7.2

Let’s go step-by-step through the best known fixes:

🧹 1. Check for “click-blocking” apps

Make sure no tools like these are installed or running:

• BetterTouchTool, Magnet, Rectangle, or Moom
• Keyboard Maestro, Karabiner-Elements, Hammerspoon
• Antivirus or security tools (Avast, McAfee, CleanMyMac, etc.)
• Remote control / screen sharing utilities (TeamViewer, AnyDesk, LogMeIn)

Quit them completely (use ⌘ + Q) or temporarily uninstall, then retry enabling the extension.

⚙️ 2. Reset Accessibility permissions

These can get stuck and block clicks inside System Settings.

Open Terminal and run:

tccutil reset Accessibility
tccutil reset All

Then restart your Mac and try again.

(You’ll have to re-grant permissions to trusted apps later.)

🪟 3. Reset System Preferences cache

Sometimes the extensions panel itself is corrupted.

Run this in Terminal:

rm -rf ~/Library/Preferences/com.apple.systempreferences.plist

Then reboot.

A known macOS issue causes an “app or service is interfering with clicking” message, often due to corrupted databases or background processes. I suggest fixes such as removing click-blocking apps, resetting Accessibility permissions, and rebuilding the TCC database.