your unsigned files appear to be limited to standard Java components. Not an issue.
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THIS might be a problem:
[Running] AppCleaner SmartDelete (Julien Ramseier - installed 2024-11-03)
Modern Login Item
/Applications/AppCleaner.app/Contents/Library/LoginItems/AppCleaner SmartDelete.app
Your Mac does not accumulate filth that requires any third-party App to clean it.
if you need to delete an App use the software-maker's Un-Installer process, ONLY.
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your last-completed Time Machine backup shows as March 14.
When your Time Machine backups are "stuck" like that, intermediate snapshots (lists of files to be backed up) will be written to the boot drive, slowing your Mac.
Open Time Machine settings and figure out why it is not going.
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You seem to be running more than one AI software, any one of which is computationally intense AND may require a lot of network bandwidth. Get rid of the ones you are not using at this moment.
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you seem to be running Backblaze, a file sync program.
Third-party file Sync-ers such as DropBox, BackBlaze, OneDrive, Carbonite, or GoogleDrive can ruin performance, but are not inherently dangerous.
They were Quickly ported from that other Operating System, and were never re-written to take advantage of the MacOS ‘File System Event Store’. The typical brute-force search they use takes all afternoon for one pass. That relentless searching is a completely un-necessary waste of resources.
Native Synch and Backup programs like iCloud Drive and Time Machine that DO use the MacOS File System Event Store can find changes really quickly and be done with their work and suspend themselves. Time machine can run backups Hourly, while all those others are still beating on the file system for the first pass, four hours later. By the time those others have finished one pass, they need to start again.
If you MUST run that, launch it only when needed. When complete, quit the App or Restart your Mac after use.
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I have noticed a correlation (not proof) that when Mac shows highest network use is mDNSResponder, it is likely spending too much time "on the phone" synchronizing or communicating with others, and not getting your real work done.