If Apple Configurator successfully detects the iPhone but Actions >> Modify >> Home Screen layout hangs indefinitely, the issue is more likely to be caused by a software bug or an unsupported device state than by a connection problem.
Apple documents that Home Screen modification should work on supported supervised devices by opening the layout editor and allowing apps to be rearranged before the changes are applied. Apple Support documentation
The first thing to verify is whether the iPhone is supervised, since Home Screen layout management is intended for supervised devices.
A supervised device is one that has been prepared for management, typically by an organization such as a business or school, although supervision can also be enabled on a personal iPhone using Apple Configurator.
However, simply connecting a personal iPhone to a personal iMac does not make the device supervised. A personal iPhone that has been set up normally is not supervised by default, and enabling supervision requires erasing the device and preparing it again through Apple Configurator.
Additional information about preparing and supervising devices is available in the Apple Configurator User Guide. Apple Configurator User Guide
If you are using a personal iMac with a personal iPhone that has never been prepared for supervision, this could explain why the Home Screen modification feature is unavailable or does not function as expected.
If your intention is to manage your own device, be aware that supervision is designed primarily for devices that are managed by organizations, although it can also be enabled on personally owned devices after they have been erased and prepared.
Organizations typically enable supervision through Apple Business Manager or Apple School Manager together with a mobile device management (MDM) solution. More information is available from Apple Business Manager and Apple School Manager. Apple Business Manager Apple School Manager
If the iPhone is already supervised and the Home Screen modification still hangs, the issue is more likely to be related to the current Apple Configurator or iOS release than to the device configuration.
It is also worth confirming that the Home Screen has finished indexing. If the iPhone was recently restored, updated, or had applications installed, wait until all applications have finished downloading and the Home Screen is fully populated before trying again, since an incomplete Home Screen can cause Apple Configurator operations to behave unexpectedly.
Restart both the iMac and the iPhone, then reconnect the devices using a certified USB-C cable connected directly to the Mac rather than through a hub. It is also helpful to test another modification, such as changing the device name or wallpaper. If those actions work but modifying the Home Screen layout continues to hang, the issue is likely specific to the Home Screen editor rather than the USB connection.
There have also been recent reports on the Apple Developer Forums describing issues with Apple Configurator 2.20 on macOS 26.5.x when working with Home Screen and application layouts on iOS 26.5.x. Although the reported symptoms are not identical, they suggest that there are active regressions affecting Home Screen layout handling. More information can be found on the Apple Developer Forums. Apple Developer Forums
If none of these steps resolves the issue, filing feedback with Apple is recommended because the behaviour appears consistent with a software regression.