The “Significant Energy” warning in macOS does not necessarily indicate a problem with your MacBook Air M2, Safari, Preview or battery.
However, if almost every app displays this warning after a few minutes of light use, it is worth investigating.
The first thing to check is Activity Monitor, rather than changing settings or uninstalling uBlock Origin Lite.
Open Applications >> Utilities >> Activity Monitor and select the Energy tab. Sort by Energy Impact and observe Safari while browsing a simple webpage without video, then leave it idle. Repeat with Preview and a small PDF.
Apple explains how to interpret these measurements here:
Apple: View energy consumption in Activity Monitor
The Energy Impact column indicates relative current energy consumption. The 12 hr Power column is a longer-term measure, not battery percentage, watts or milliamp-hours. Consequently, a value of 300 does not mean Safari has consumed 300% of your battery.
Safari can temporarily use more energy when playing YouTube videos, processing webpages, running scripts or handling advertisements. Preview can also use more energy while rendering or processing PDFs. What matters is whether energy consumption remains elevated when the applications are idle.
You can test whether your Safari extensions contribute by temporarily disabling them under Safari >> Settings >>> Extensions.
Repeat the same browsing test, then re-enable extensions individually. This will help determine whether uBlock Origin Lite or another extension is contributing.
YouTube video resolution and background webpage activity can also affect Safari's energy use, so compare the same video and settings when testing.
Your screenshot shows Battery Health as Normal, which is reassuring, but the Battery settings graphs show overall energy usage and screen-on time.
They do not identify individual applications' energy consumption.
Apple's explanation of the battery usage information is available here:
Apple: Check the battery usage on your Mac laptop
My recommendation: Before changing other settings, check Safari's Energy Impact and 12 hr Power in Activity Monitor, both while actively browsing and while idle. Also check Preview under the same conditions.
Those measurements will help determine whether the behaviour is temporary and expected or whether a particular application or background process warrants further investigation.