iTunes not opening when iPhone connected

Hi

My iTunes used to open and start syncing immediately I connected my iPhone - now it does not.

I've made sure the 'open iTunes when this iPhone is connected' box is ticked, switched off the iPhone and restarted it, restarted my MacBook, reset the sync history, deleted podcasts, restored the iPhone - nothing works.

Is this an iPhone OS 4.1 issue?

I'm running an 3GS iPhone with 4.1, iTunes vers. 10, on a MacBook OS X 10.5.8