I recently got a Mac Pro 8-core (Intel Xeon), and have been experiencing constant hard drive activity, but not from the beginning, so it had to come from something I installed.
First off I connected my laptop via firewire and ran Disk Warrior. There were acute problems, as part of the DW conclusion text was in red. After repair, and restart, I found that the the disc activity continued. I saw this thread and the link to another thread prompted me to uninstall Adobe CS3. That did the trick. After a reboot, I ran the CS5 Cleaner program, but that didn't seem to find anything after the uninstall. All that remained was to delete the cache.db in /Library/Application Support/Adobe/Adobe PCD/cache/. I rebooted again for good measure. Voila! No more disc activity. I think I'll try re-installing Adobe CS one program at a time, and not do them all in one install. That way, if the disc activity starts up again, I'll know which program did it. Hopefully, that won't happen, and all the demons are exorcised from this machine.