Since no one's answered...
I didn't know Sandisk still made this thing. I beleive it came out in 2006 or 2007. A quick search on Sandisk's site, shows no driver or firmware updates, mentions "OS X 10.1" (I saw it, but can find the link), and only mentions " all Capacities - 2, 4 and 8GB." So the info seems a bit out of date, which corroborates the age of the product. [This post on the Sandisk forum|http://forums.sandisk.com/t5/Readers-adapters-and-all-other/Sandisk-Expre sscard-reader-for-eXtreme-CompactFlash-Cards/m-p/189160/highlight/true#M286] infers that the Firewire readers were discontinued, although that seems not to be true.
That said, does the issue happen with all of your CF cards or just one of them? (Or some of them?) Are the cards fast enough for the extra performance of the Firewire reader? (IOW, if they worked on a USB reader, but have issues with the FW reader, then perhaps they cards are too slow? I'm just guessing.) Or maybe even the cards are worn out. All flash memory will eventually wear out. Are these older cards? (More than 2 years old?)
It likely is a compatibility issue with 10.6.4, but I don't know of that many non-pro photographers that used a Firewire CF reader so don't hold your breath waiting for an answer here. If you can't get an answer from Sandisk, then you might have better luck in a photography based forum like [DPReview|http://www.dpreview.com>, especially something more pro oriented.