Is this on a drive, folder, or file? If it's a drive then do this:
Select the drive's Desktop icon. Press COMMAND-I to open the Get Info window. At the bottom look for a checkbox labeled, "Ignore permissions on this volume." If it is checked then click on the lock icon and authenticate. Uncheck the box. Leave the window open.
Open the Terminal application in your Utilities folder. At the prompt enter:
sudo chown root:admin
Put a space after "admin" then drag the drive's Desktop icon into the Terminal window. Press RETURN. Enter your admin password when prompted. It will not be echoed.
killall Finder
Press RETURN.
This should fix the issue. Re-open the Get Info window for the drive to verify.
If this drive is a startup volume, then I suggest doing the following:
Repair the Hard Drive and Permissions
Boot from your OS X Installer disc. After the installer loads select your language and click on the Continue button. When the menu bar appears select Disk Utility from the Utilities menu. After DU loads select your hard drive entry (mfgr.'s ID and drive size) from the the left side list. In the DU status area you will see an entry for the S.M.A.R.T. status of the hard drive. If it does not say "Verified" then the hard drive is failing or failed. (SMART status is not reported on external Firewire or USB drives.) If the drive is "Verified" then select your OS X volume from the list on the left (sub-entry below the drive entry,) click on the First Aid tab, then click on the Repair Disk button. If DU reports any errors that have been fixed, then re-run Repair Disk until no errors are reported. If no errors are reported click on the Repair Permissions button. Wait until the operation completes, then quit DU and return to the installer. Now restart normally.
If DU reports errors it cannot fix, then you will need Disk Warrior and/or Tech Tool Pro to repair the drive. If you don't have either of them or if neither of them can fix the drive, then you will need to reformat the drive and reinstall OS X.