OS X startup disk has no more space available for application memory
"Your Mac OS X startup disk has no more space available for application memory. To avoid problems with your computer, quit any applications you are not using, Closing windows and removing files from your startup disk will also help."
HD Space 361.27GB Free of 620
2.6GHz Intel Core 2 Dou
Memery 4 GB 1067MHz
iMac, Mac OS X (10.6.6)