I am not a Network guru, but I am managing a new implementation of Network, and GP for our company of 35 people. We are primiarily a Mac shop, but also use VMWare for Windows on most of our Macs, and also have several Windows machines, and we use SQL.
The one thing we discovered with Centrify for Mac is that it doesn't have all the same features as the Windows version does. (Specifically, you can't open a helpdesk ticket directly from the App in Mac, but you can in the Windows version). Our Mac users have to submit helpdesk support tickets through the URL instead. Inconvenient, but not a show-stopper.
The bigger issue we are having is as we migrate Macs into the GP for the first time, the Centrify App installs a new Mac Profile on the users machine. A user who already has a user profile on his/her Mac with all of her preferences, etc, has to re-do everything in the new profile. Very inconvenient. We haven't yet found a work-around for this.