I have been interested in upgrading my Macbook Pro 17" i5 (2.53) (6,1) to 16GB of RAM, and I have read most of this thread. It appears that the general concensus is that Macbook Pro models 6,1 and 6,2 respectively cannot seem to fluently access 16GB of RAM, however with a quick Google search, I came across this post on ifixit.
I will quote the first comment: Also as an update. with Mavericks installed, I upgraded and ran 16GB on a 2010 17" Macbook Pro (2.53Ghz i5 with nVidia GT330M 512MB) which were all previously software limited to only 8GB!!
So it would seem that under Mavericks it can boot correctly. I would love to test this out if I could, but I'm not in a position to do that. I currently have 4GB installed, which frankly, is not cutting it anymore. I temporarily had 8GB (1333mhz) installed, and it downclocked the chips to 1067. The chips are my brothers, so I had to return them.
I want to officially update to more RAM, so it would be nice to hear a good report on 16GB, or if I'll just have to settle for 8GB.
On a side note, my brothers Macbook 5,1 runs 8GB of RAM clocked at 1333mhz (not downclocked) without a hitch, even though Apple officially supports 4GB at 1067mhz. His computer crashes sometimes, but when I replaced his RAM with mine to see if it was because of the speed difference, it still crashed. However, mine chumped up that 8GB like it was made for it! 😝