buttons do not work when I work in adobe photoshop + illustrator cs5

Please help me. I have two computers, but the Macbook AIR is a problem. I work in Photoshop and Illustrator cs5 and after some time, I do not work the buttons (only letters)... Correct the problem can only restart if the MacBook. What could be the problem?? I tried to create a second user - there is no such problem, but I can not bear all: (