I have been syncing between my iPad and pc without any problems since date of purchase last October until the most recent update download on iTunes in readiness for new OS4.3 update. After successfully updating iTunes and then my iPad albeit a few scares in the process when I thought I had lost all of my previous iPad back-up, syncing now appears to be rather tempermental between iPad and PC; iTunes would freeze on pc after a few minutes of syncing hundreds of photos from pc to iPad. I had to re-start my pc in order to continue with syncing. I thought perhaps to completely uninstall iTunes from pc and then reinstall latest version of iTunes would solve this problem on my pc. However, I wonder if I uninstall, would I lose everything of my iPad back-up on pc?